| 摘要: |
| ［摘要］ 目的 观察急性ST段抬高心肌梗死患者急诊介入治疗前应用替罗非班的临床效果。方法 选择该院2012-06～2015-06收治的113例急性ST段抬高心肌梗死患者作为研究对象，按随机数字表法分为观察组57例和对照组56例。观察组于冠状造影后立即应用替罗非班0.5 mg静脉注射，然后行急诊经皮冠状动脉介入治疗（PCI）。对照组冠状造影后行急诊PCI，于第1次球囊扩张后冠脉内注射替罗非班0.5 mg。比较两组梗死相关血管TIMIⅢ级患者所占比例、住院期间心血管事件发生率、出血发生率。结果 观察组梗死相关血管TIMIⅢ级患者所占比例为42.1%（24/57），高于对照组的23.2%（13/56），差异有统计学意义(P<0.05）。观察组和对照组出血发生率分别为5.3%（3/57）和7.1%（4/56），差异无统计学意义(P>0.05）。两组住院期间再梗死、心源性休克、心力衰竭、死亡等心血管事件发生率比较差异均无统计学意义(P>0.05）。结论 急性ST段抬高心肌梗死患者于急诊介入治疗前应用替罗非班可在一定程度上恢复术前血流，梗死相关血管TIMIⅢ级患者所占比例更高，且安全性好，不增加出血事件与住院期间心血管事件，值得借鉴。 |
| 关键词: ST段抬高心肌梗死 介入治疗 替罗非班 冠状造影 |
| DOI：10.3969/j.issn.1674-3806.2016.10.19 |
| 分类号:R 542.2+2 |
| 基金项目: |
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| Clinical effects of tirofiban on the treatment of acute ST segment elevation myocardial infarction before emergency interventional therapy |
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SONG Xin-hua
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Department of Emergency, Central Hospital of Jiaozuo Coal Industry(Group) Limited Liability Company, Henan 454150, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical effect of tirofiban on the treatment of acute ST segment elevation myocardial infarction(STEMI) before emergency interventional therapy.Methods One hundred and thirteen patients with STEMI who were admitted to our hospital from June 2012 to June 2015 were selected as the study subjects. According to the random number table method, the patients were divided into the observation group(n=57) and the control group(n=56). The observation group was immediately treated with tirofiban 0.5 mg, intravenous injection after coronary angiography. Then, they were treated with emergency coronary interventional surgery. The control group was treated with emergency PCI after coronary angiography and 0.5 mg tirofiban was injected into the coronary artery after the first-time balloon dilatation. The proportions of the patients with infarct related blood vessel TIMI grade Ⅲ, the incidence of the cardiovascular events and bleeding during hospitalization were compared between the two groups.Results The proportion of the patients with infarct related blood vessel TIMI grade Ⅲ in the observation group(42.1%) was higher than that in the control group(23.2%)(P<0.05); The incidence of bleeding was 5.3% in the observation group and 7.1% in the control group(P>0.05). There were no statistically significant differences in the incidences of re-infarction, cardiogenic shock, heart failure, death and other cardiovascular events between the two groups during the hospitalization(P>0.05).Conclusion The application of tirofiban before emergency interventional therapy for the patients with STEMI makes preoperative blood quickly flow to a certain extent and makes the proportions of patients with infarct related blood vessel TIMI grade Ⅲ higher, but the bleeding events and cardiovascular events are not increased during the hospitalization. |
| Key words: ST segment elevation myocardial infarction Interventional therapy Tirofiban Coronary angiography |
