| 摘要: |
| ［摘要］ 目的 观察阻塞性睡眠呼吸暂停低通气综合征（OSAHS）及合并高血压（HT）患者肿瘤坏死因子α（TNF-α）的变化及临床意义。方法 收集2013-08～2015-09确诊的OSAHS患者157例，其中血压正常者为单纯OSAHS组57例，OSAHS合并高血压患者为OSAHS+HT组100例，以正常人15名作为对照组。进行整夜多导睡眠图检查，观察指标包括呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)及平均血氧饱和度(MSaO2)等；采用双抗体夹心酶联免疫吸附（ELISA）法测定血清TNF-α。结果 血清TNF-α:OSAHS组、OSAHS+HT组较对照组增高(P均<0.05)，OSAHS+HT组较OSAHS组增高(P<0.05)。MSaO2和LSaO2：OSAHS组、OSAHS+HT组较对照组降低（P均<0.05）。就诊收缩压和舒张压：OSAHS组、OSAHS+HT组均较对照组增高（P均<0.05），OSAHS+HT组较OSAHS组增高(P均<0.05)。相关分析显示,OSAHS组和OSAHS+HT组AHI与TNF-α呈显著正相关(P<0.05),AHI、TNF-α与MSaO2和LSaO2均呈显著负相关(P均<0.05)。结论 OSAHS及OSAHS合并HT的发生均可能与炎症因子TNF-α水平增高有关。 |
| 关键词: 睡眠呼吸暂停低通气综合征 高血压 肿瘤坏死因子α |
| DOI：10.3969/j.issn.1674-3806.2016.12.01 |
| 分类号:R 56 |
| 基金项目:国家自然科学基金资助项目（编号：81160014）；广西自然科学基金资助项目（编号：2014GXNSFAA118261） |
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| The detection and clinical significance of serum TNF-α in patients with obstructive sleep apnea hypopnea syndrome complicated with hypertension |
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LIANG Da-hua, XIE Yu-ping, LIU Jian-hong, et al
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Sleep-disordered Breathing Center of Guangxi, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe the changes and clinical value of tumor necrosis factor alpha（TNF-α） in the patients with obstructive sleep apnea hypopnea syndrome(OSAHS) complicated with hypertension(HT).Methods A total of 157 OSAHS patients diagnosed between August 2013 and September 2015 were recruited, with 57 cases in OSAHS group and 100 cases in OSAHS+HT group, and 15 healthy people were taken as the control group. All the groups were monitored by polysomnography, and the apnea hypopnea index(AHI), the lowest blood oxygen saturation(LSaO2) and mean blood oxygen saturation(MSaO2) were oberved. The serum TNF-α in the patients was detected by double antibody sandwich enzyme linked immunosorbent assay(ELISA).Results TNF-α levels in OSAHS group and OSAHS+HT group were significantly higher than those in the control group(P<0.05), and TNF-α levels in OSAHS+HT group were significantly higher than those in OSAHS group(P<0.05). Compared with those in the control group, MSaO2 and LSaO2 in OSAHS group and OSAHS+HT group were significantly decreased(P<0.05). The systolic blood pressure and diastolic blood pressure at the first admission to the clinic in OSAHS group and OSAHS+HT group were significantly higher than those in the control group(P<0.05), and the blood pressure in OSAHS+HT group was significantly higher than that in OSAHS group(P<0.05). The correlation analysis suggested that there were significantly positive correlations between AHI and TNF-α in both OSAHS group and OSAHS+HT group(P<0.05), and that there were significantly negative correlations between AHI, TNF-α and MSaO2 and LSaO2(P<0.05).Conclusion The incidence of OSAHS and OSAHS complicated with hypertension may be associated with the increased levels of inflammatory factor TNF-α. |
| Key words: Sleep apnea hypopnea syndrome Hypertension Tumor necrosis factor alpha |
