| 摘要: |
| ［摘要］ 延迟性脑缺血(delayed cerebral ischemia,DCI)作为影响动脉瘤性蛛网膜下腔出血后神经功能损伤重要原因，曾一度被理解为是仅由脑血管痉挛导致的，有部分学者甚至将DCI直接定义为发生脑血管痉挛的不良预后。但目前研究表明，造成DCI的相关发病机制可能不止如此，目前获得较多认同的机制有：早期脑损伤、皮质弥散去极化、微血栓形成、微循环痉挛、脑血流自动调节障碍、氧化应激和活性氧自由基生成，其他机制如细胞死亡、炎症反应、血脑屏障破坏等。该文对动脉瘤性蛛网膜下腔出血后DCI的研究进展作一综述。 |
| 关键词: 动脉瘤性蛛网膜下腔出血 延迟性脑缺血 发病机制 |
| DOI：10.3969/j.issn.1674-3806.2020.05.26 |
| 分类号:R 743.35 |
| 基金项目: |
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| Research progress in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage |
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LI Xue-feng, WANG Jian-cun, HU Guan-cheng
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Jishou University School of Medicine, Hunan 416000, China
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| Abstract: |
| ［Abstract］ Delayed cerebral ischemia(DCI), as an important cause of neurological impairment after aneurysmal subarachnoid hemorrhage(aSAH), was once understood to be caused only by cerebral vasospasm and some scholars also directly defined DCI as the adverse prognosis of cerebral vasospasm. However, current researches show that the potential pathogenesis of DCI may be more than that. At present, there are more recognized mechanisms: early brain injury, cortical spreading depolarizations, microthrombosis, microvascular spasm, cerebral blood flow autoregulation disorders, oxidative stress and reactive oxygen species free radical production, and other mechanisms, such as cell death, inflammatory response, blood-brain barrier damage, etc. In this paper, we review the research progress in DCI after aSAH. |
| Key words: Aneurysmal subarachnoid hemorrhage(aSAH) Delayed cerebral ischemia(DCI) Pathogenesis |
