| 摘要: |
| ［摘要］ 目的 探讨康艾注射液联合化疗对晚期肺鳞癌患者临床疗效和免疫功能及生活质量的影响。方法 收集2017年7月至2020年10月广东医科大学附属医院94例肺鳞癌初治患者，按照随机数字表法分为对照组（45例）和观察组（49例）。对照组接受顺铂+吉西他滨化疗，观察组在对照组的基础上联合康艾注射液辅助治疗，两组均治疗4个疗程。比较两组治疗前后T细胞计数、治疗后的临床疗效、生活质量评分及化疗不良反应情况。结果 治疗后，观察组的客观缓解率高于对照组，差异有统计学意义（P<0.05），但两组的疾病控制率差异无统计学意义（P>0.05）；观察组KPS评分高于对照组，差异有统计学意义（P<0.05）；观察组T淋巴细胞总数、T辅助细胞绝对值、T抑制细胞绝对值高于对照组，差异有统计学意义（P<0.05）；观察组恶心呕吐、血小板减少、白细胞减少不良反应发生率低于对照组，差异有统计学意义（P<0.05）。结论 康艾注射液联合化疗可提高晚期肺鳞癌患者免疫功能和生活质量，降低不良反应，从而提高临床疗效，值得临床推广。 |
| 关键词: 肺鳞癌 化疗 康艾注射液 免疫功能 生活质量 |
| DOI：10.3969/j.issn.1674-3806.2021.08.18 |
| 分类号:R 734.2 |
| 基金项目: |
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| Effects of Kang′ai injection combined with chemotherapy on clinical efficacy, immune function and quality of life in patients with lung squamous cell carcinoma |
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HUANG Zhong, LIU Mei-lian, PENG Xiao-xia, et al.
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Pulmonary Tumor Ward, Tumor Hospital, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effects of Kang′ai injection combined with chemotherapy on clinical efficacy, immune function and quality of life in patients with advanced lung squamous cell carcinoma. Methods A total of 94 lung squamous cell carcinoma patients who were newly treated in the Affiliated Hospital of Guangdong Medical University from July 2017 to October 2020 were collected and divided into control group(45 cases) and observation group(49 cases) according to random number table method. The control group received cisplatin plus gemcitabine chemotherapy. The observation group received the same treatment as the control group plus adjuvant therapy with Kang′ai injection. Both groups were treated for 4 courses. T cell counts before treatment and after treatment, and the clinical efficacy, quality of life score and adverse reactions of chemotherapy after treatment were compared between two groups. Results After treatment, the objective response rate of the observation group was significantly higher than that of the control group(P<0.05), but there was no significant difference in the disease control rate between the two groups(P>0.05). The Karnofsky Performance Status(KPS) scores of the observation group were significantly higher than those of the control group after treatment(P<0.05). The total number of T lymphocytes, absolute value of T helper cells and absolute value of T suppressor cells in the observation group were significantly higher than those in the control group after treatment(P<0.05). The incidence rates of adverse reactions of nausea and vomiting, thrombocytopenia and leukopenia in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Kang′ai injection combined with chemotherapy may improve the immune function and quality of life of patients with advanced lung squamous cell carcinoma, reduces the adverse reactions of the patients, thus improves the clinical efficacy,which is worthy of clinical promotion. |
| Key words: Lung squamous cell carcinoma Chemotherapy Kang′ai injection Immune function Quality of life |
