| 摘要: |
| ［摘要］ 目的 分析中性粒细胞与高密度脂蛋白胆固醇比值（NHR）与急性冠脉综合征（ACS）患者冠状动脉狭窄程度的关联性。方法 回顾性收集2021年5月至2022年5月苏北人民医院心血管内科收治的270例ACS患者的临床资料，均行冠状动脉造影(CAG)检查。依据Gensini评分将其分为低GS组（Gensini评分≤48分，130例）和高GS组（Gensini评分>48分，140例）。采用二元logistic回归分析高Gensini评分ACS发生的独立影响因素。采用受试者工作特征（ROC）曲线分析NHR对高、低Gensini评分ACS的鉴别诊断效能。结果 高GS组合并糖尿病的人数比例高于低GS组，中性粒细胞(NEU)、血小板（PLT）、单核细胞（MON）、NHR水平高于低GS组，淋巴细胞(LYM)、血清白蛋白（ALB）水平低于低GS组，差异有统计学意义（P<0.05）。二元logistic回归分析结果显示，合并糖尿病（OR=1.873）和较高水平的NHR（OR=1.430）是促进高Gensini评分ACS发生的独立影响因素（P<0.05），较高水平的LYM(OR=0.585)、ALB(OR=0.931)是抑制高Gensini评分ACS发生的独立影响因素（P<0.05）。ROC曲线分析结果显示，NHR具有鉴别诊断高、低Gensini评分ACS的应用价值［AUC(95%CI)=0.710（0.649～0.770），P<0.001］，最佳截断值为7.40，其对应的特异度为83.1%，灵敏度为51.4%。结论 NHR与冠状动脉狭窄程度呈正关联，对ACS患者冠脉严重程度有一定的诊断价值。 |
| 关键词: 急性冠脉综合征 中性粒细胞与高密度脂蛋白胆固醇比值 Gensini评分 冠状动脉狭窄 |
| DOI：10.3969/j.issn.1674-3806.2023.03.12 |
| 分类号:R 541.4 |
| 基金项目: |
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| Analysis on the correlation between neutrophil-to-high density lipoprotein cholesterol ratio and the severity of coronary artery stenosis in patients with acute coronary syndrome |
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HUANG Jing, XU Ri-xin, WANG Da-xin
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Clinical Medical College of Yangzhou University, Jiangsu 225001, China
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| Abstract: |
| ［Abstract］ Objective To analyze the correlation between neutrophil-to-high density lipoprotein cholesterol ratio(NHR) and the severity of coronary artery stenosis in patients with acute coronary syndrome(ACS). Methods The clinical data of 270 ACS patients admitted to the Department of Cardiology of Subei People′s Hospital from May 2021 to May 2022 were retrospectively collected, and coronary artery angiography(CAG) was performed on the patients. According to different Gensini scores, the patients were divided into low GS group(Gensini scores ≤48 points, 130 cases) and high GS group(Gensini scores>48 points, 140 cases). Binary logistic regression was used to analyze the independent influencing factors of ACS patients with high Gensini scores. Receiver operating characteristic(ROC) curve was used to analyze the differential diagnostic efficacy of NHR in the ACS patients with high and low Gensini scores. Results The proportion of the patients complicated with diabetes in the high GS group was higher than that in the low GS group. The levels of neutrophils(NEU), platelets(PLT), monocytes(MON) and NHR in the high GS group were higher than those in the low GS group, and the levels of lymphocytes(LYM) and serum albumin(ALB) in the high GS group were lower than those in the low GS group, and the differences were statistically significant(P<0.05). The results of binary logistic regression analysis showed that concomitant diabetes(OR=1.873) and high level of NHR(OR=1.430) were the independent influencing factors promoting the occurrence of ACS in the patients with high Gensini scores(P<0.05), while high levels of LYM(OR=0.585) and ALB(OR=0.931) were the independent influencing factors inhibiting the occurrence of ACS in the patients with high Gensini scores(P<0.05). The results of ROC curve analysis showed that NHR had the application value of differentiating the ACS patients with high Gensini scores from the ACS patients with low Gensini scores［AUC(95%CI)=0.710(0.649-0.770), P<0.001］, and the optimum cut-off value was 7.40, and the corresponding specificity and sensitivity were 83.1% and 51.4%. Conclusion NHR is positively correlated with the degree of coronary artery stenosis, and has a certain diagnostic value for the severity of coronary artery in ACS patients. |
| Key words: Acute coronary syndrome(ACS) Neutrophil-to-high density lipoprotein cholesterol ratio(NHR) Gensini score Coronary artery stenosis |
