| 摘要: |
| ［摘要］ 目的 观察丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床疗效。方法 选择2016-01～2017-06收治的急性脑梗死患者80例，按随机数字表法分为依达拉奉组和联合组，每组40例，分别在常规治疗的基础上给予依达拉奉治疗和丁苯酞联合依达拉奉治疗，2周为一疗程。比较两组患者治疗前后美国国立卫生院卒中量表（NIHSS）评分变化、临床疗效以及脑梗死灶体积变化情况。结果 两组患者治疗后NIHSS评分较治疗前降低，差异有统计学意义（P<0.05），且联合组治疗后NIHSS评分降低较依达拉奉组显著，差异有统计学意义（P<0.05）。联合组基本治愈10例，显著进步11例，进步14例，无变化3例，恶化2例，依达拉奉组分别为4例、7例、13例、10例和6例，联合组的临床疗效明显优于依达拉奉组（P<0.05）。两组患者治疗后脑梗死灶体积缩小（P<0.05），且联合组缩小体积明显大于依达拉奉组（P<0.05）。结论 丁苯酞注射液联合依达拉奉治疗急性脑梗死，可以有效提高患者生活质量，提高治疗有效率，减少急性脑梗死后梗死体积，值得临床推广。 |
| 关键词: 丁苯酞注射液 依达拉奉 急性脑梗死 美国国立卫生院卒中量表评分 |
| DOI：10.3969/j.issn.1674-3806.2019.10.22 |
| 分类号:R 743.3 |
| 基金项目: |
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| Therapeutic effect of butylphthalide injection combined with edaravone on acute cerebral infarction |
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LUO Wei-li, LIU Te-jiong, LIN Zhi-jia
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The First Department of Neurology, the People′s Hospital of Puning City, Guangdong 515300, China
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| Abstract: |
| ［Abstract］ Objective To observe the therapeutic effect of butylphthalide injection combined with edaravone on acute cerebral infarction. Methods Eighty cases of acute cerebral infarction treated in our department from January 2016 to June 2017 were randomly divided into the combination group and the edaravone group, with 40 cases in each group. On the basis of routine treatment, the combination group was treated with butylphthalide injection combined with edaravone and the edaravone group was treated with edaravone. Both of the two groups were treated for 2 weeks and two weeks was a course of treatment. The changes of the National Institutes Health Stroke Scale(NIHSS) scores, the clinical therapeutic effect and the volume of the cerebral infarction were compared between the two groups before and after treatment. Results Compared with those before treatment, the NIHSS scores were significantly lower in the two groups after treatment(P<0.05), and the NIHSS scores of the combination group were significantly lower than those of the edaravone group after treatment（P<0.05）. In the combination group, 10 cases were cured, 11 remarkably effective, 14 effective, 3 ineffective and 2 exacerbated. In the edaravone group, 4 cases were cured, 7 remarkably effective, 13 effective, 10 ineffective and 6 exacerbated. The therapeutic effect of the combination group was better than that of the edaravone group（P<0.05）. Compared with those before treatment, the volumes of the cerebral infarction in the two groups reduced greatly（P<0.05）, and the reduction volume of the combination group was significantly greater than that of the edaravone group（P<0.05）. Conclusion Butylphthalide injection combined with edaravone can improve the quality of life and the effective rate, and reduce the volume of infarction in the patients with acute cerebral infarction. |
| Key words: Butylphthalide injection Edaravone Acute cerebral infarction The National Institutes Health Stroke Scale(NIHSS) score |
