| 摘要: |
| ［摘要］ 急性缺血性脑卒中（AIS）是一种发病率、致残率和病死率均较高的严重血栓性疾病，发病机制复杂，血栓形成与无菌性炎症是核心病理过程。中性粒细胞胞外诱捕网（NETs）是由中性粒细胞活化后释放的纤维网状结构，不仅参与宿主病原体防御，而且还在血栓性疾病的病理过程中发挥关键作用。NETs可启动并放大血栓与炎症级联反应，诱发脑组织损伤，加重AIS进展及恶化。该文对NETs介导AIS病理生理与临床应用转化的研究进展作一综述。 |
| 关键词: 中性粒细胞胞外诱捕网 急性缺血性脑卒中 血栓形成 炎症反应 |
| DOI：10.3969/j.issn.1674-3806.2026.03.22 |
| 分类号:R 743.3 |
| 基金项目:云南省科技厅科技计划项目（编号：202301AY070001-097）；昆明市卫生健康委员会卫生科研课题项目（编号：2025-11-01-001）；昆明医科大学研究生教育创新基金项目（编号：2025S124） |
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| Research progress in the pathophysiological mechanism and clinical translational application of neutrophil extracellular traps-mediated acute ischemic stroke |
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WANG Yaxin1, ZHANG Yixin1, YIN Limin1,2, PU Kuairong2, ZHAO Xiaoli1,2
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1.Medical Laboratory Center, Ganmei Affiliated Hospital of Kunming Medical University, Kunming 650011, China; 2.Medical Laboratory Center, the First People′s Hospital of Kunming, Kunming 650011, China
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| Abstract: |
| ［Abstract］ Acute ischemic stroke(AIS) is a severe thrombotic disease with high incidence, disability and mortality rates. Its pathogenesis is complex, and thrombosis and aseptic inflammation are the core pathological processes. Neutrophil extracellular traps(NETs) are fibrous mesh-like structures released by activated neutrophils, which not only participate in host defense against pathogens but also play a crucial role in the pathological processes of thrombotic disease. NETs can initiate and amplify the thrombus-inflammation cascade, induce brain tissue damage, and aggravate the progression and deterioration of AIS. In this paper, the research progress in NETs-mediated AIS is reviewed. |
| Key words: Neutrophil extracellular traps(NETs) Acute ischemic stroke(AIS) Thrombosis Inflammatory response |
