| 摘要: |
| ［摘要］ 目的 比较地塞米松鼓室内注射与静脉给药治疗突发性聋的临床疗效。方法 将180例初次治疗的突发性聋患者分为A组和B组,每组90例，两组根据听力损失程度又分为A1、A2组和B1、B2组,PTA≤70 dB患者为A1、B1组,PTA>70 dB患者为A2、B2组。A组采用常规疗法加静脉注射地塞米松治疗,B组采用常规疗法加鼓室注射地塞米松治疗,比较各组治疗效果。结果 （1）B组临床疗效和总有效率均优于A组（P均<0.05）。（2）A1组总有效率为72.00%(36/50),A2组总有效率为40.00%(16/40),B1组总有效率为81.25%(39/48),B2组总有效率为61.90%(26/42);A1组与A2组、B1组与B2组及A2组与B2组差异有统计学意义(P<0.05),而A1组与B1组差异无统计学意义(P>0.05)。结论 同一种治疗方法,听力损失程度与疗效有密切关系,因此对PTA≤70 dB的患者应根据患者的实际情况决定给药途径,而对PTA>70 dB的患者,如情况允许应尽可能用鼓室注射地塞米松治疗。 |
| 关键词: 突发性聋 静脉注射 鼓室注射 地塞米松 |
| DOI：10.3969/j.issn.1674-3806.2013.06.17 |
| 分类号:R 764 |
| 基金项目: |
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| Observation on curative effect of intratympanic versus intravenous administration of dexamethasone in the treatment of sudden sensorineural hearing loss |
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XU Sheng-hui,GUO Yi-lian
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Department of Otolaryngology, Dayong Hospital of Zhongshan City, Guangdong 528476, China
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| Abstract: |
| ［Abstract］ Objective To compare the clinical curative effect between intratympanic and intravenous administration of dexamethasone in the treatment of sudden sensorineural hearing loss(SSNHL).Methods One hundred and eighty patients with SSNHL receiving primary treatment were randomly divided into group A and group B, each group of 90 cases. Then according to the degree of hearing loss, PTA≤70 dB patients were divided into A1 group and B1 group, PTA>70 dB patients divided into A2 group and B2 group. Group A was treated with conventional therapy combined with intravenous therapy of dexamethasone, group B with conventional therapy plus intratympanic administration of dexamethasone. The therapeutic effect between two groups were compared.Results (1)The clinical effect and total effective rate in B group were better than those in A group（P all<0.05）.(2)A1 group’s total effective rate was 72.00%(36/50), A2 group’s total effective rate was 40.00%(16/40), B1 group’s total effective rate was 81.25%(39/48), B2 group’s total effective rate was 61.90%(26/42); Between A1 group and A2 group,between B1 group and B2 group and between A2 group and B2 group there were statistically significant difference(P<0.05), and between A1 group and B1 group there was no statistically significant difference(P>0.05).Conclusion Between the degree of hearing loss and the curative effect there is a close relationship in the same kind of treatment.So to patients with PTA ≤70 dB,it should be necessary to select the route of administration on the basis of the actual situation of patients and to patients with PTA>70dB,if cirumstances permit intratympanic administration of dexamethasone should be used as far as possible. |
| Key words: Sudden sensorineural hearing loss (SSNHL) Intravenous injection Intratympanic injection Dexamethasone |
