| 摘要: |
| ［摘要］ 目的 探讨视黄醇结合蛋白（RBP）、前白蛋白（PA）、总胆汁酸（TBA）、胆碱酯酶（CHE）在不同类型肝脏疾病中的临床价值。方法 应用全自动生化分析仪分别检测110例不同类型肝脏疾病患者RBP、PA、TBA、CHE、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）水平，观察不同肝病组各项指标的变化，并与68名健康体检者（健康对照组）进行对比分析。结果 重症肝炎组、肝硬化组及肝癌组中RBP、PA浓度显著低于健康对照组（P<0.01）；五组肝病患者TBA水平显著高于健康对照组（P<0.01）；重症肝炎组、肝硬化组及肝癌组中的CHE活力显著低于健康对照组（P<0.01）；急性病毒性肝炎组、重症肝炎组ALT、AST活力显著高于健康对照组（P<0.01）。结论 检测血清RBP、PA、TBA、CHE对肝脏疾病的诊断、治疗和判断预后有一定的临床意义，在反映肝脏实质性病变程度方面优于ALT、AST。ALT、AST检测同时联合RBP、PA、TBA、CHE检测能更好地反映肝脏功能。 |
| 关键词: 视黄醇结合蛋白 前白蛋白 总胆汁酸 胆碱酯酶 肝脏疾病 |
| DOI：10.3969/j.issn.1674-3806.2014.07.13 |
| 分类号:R 575 |
| 基金项目: |
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| The clinical value of detection of RBP, PA, TBA, CHE in different types of liver disease |
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YAO Bi-wan
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Department of Clinical Laboratory, Chinese Medicine Hospital of Wuzhou, Guangxi 543002, China
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| Abstract: |
| ［Abstract］ Objective To study the clinical value of RBP, PA, TBA, CHE in different types of liver disease.Methods The levels of RBP, PA, TBA, CHE, alanine aminotransferase(ALT), aspartate aminotransferase(AST) in 110 patient with different types of liver disease were detected respectively by automatic biochemistry analyzer to observe changes in different liver disease groups, and 68 healthy persons(control group) were analyzed at the same time.Results The levels of RBP, PA in severe hepatitis group, cirrhosis and liver cancer groups were significantly lower than that in healthy controls (P<0.01). The TBA levels in 5 groups of patients with liver disease was significantly higher than that in healthy controls(P<0.01). But the cholinesterase activity in severe hepatitis, cirrhosis and liver groups were significantly lower than that in the control group(P<0.01). The activity of ALT and AST in acute viral hepatitis, severe hepatitis groups were increased significantly.Conclusion It is suggested that detecting the levels of RBP, PA, TBA, CHE has some clinical significance for the diagnosis, treatment, and prognosis of liver disease, and is better than of detecting ALT, AST in the reflect the liver substantive lesions. Detection combined with RBP, PA, TBA, CHE can better reflect liver function. |
| Key words: Retinol binding protein Prealbumin Total bile acid Cholinesterase Liver disease |
