| 摘要: |
| ［摘要］ 目的 探讨舌鳞状细胞癌组织中活性氧的标志物8-羟基脱氧鸟苷（8-OHdG）和磷酸化表皮生长因子受体（p-EGFR）的表达水平，并分析二者的相互关系。方法 应用免疫组化法检测30例舌鳞癌组织及其癌旁组织中8-OHdG和p-EGFR表达，通过相关性分析探讨两者之间的关系。结果 8-OHdG和p-EGFR在舌癌组织中高表达,阳性表达率分别为80.0%、56.7%；两者在癌旁组织中呈低表达,阳性表达率分别为16.7%、6.7%，它们在癌组织中的阳性表达率均显著高于癌旁组织(P<0.05),8-OHdG的表达与p-EGFR的表达具有显著相关性（P<0.05）。结论 该研究初步确定活性氧在口腔癌中的表达和作用，以及其与磷酸化EGFR的正相关性。 |
| 关键词: 活性氧 磷酸化表皮生长因子受体 舌鳞癌 免疫组化 |
| DOI：10.3969/j.issn.1674-3806.2016.05.02 |
| 分类号:R 739.8 |
| 基金项目:国家自然科学基金资助项目(编号:81360403) |
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| Expressions of 8-OHdG and phospho-epithelial growth factor receptor in tongue squamous cell carcinoma and their correlation |
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QIN Xiang-ming, CHEN Lei, YU Da-hai, et al.
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Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To detect the expressions of 8-hydroxydeoxyguanine(8-OhdG) and phospho-epithelial growth factor receptor(p-EGFR) in tongue squamous cell carcinoma(TSCC) and their correlation.Methods The expressions of 8-OHdG and p-EGFR in 30 specimens of tongue squamous cell carcinoma tissues and adjacent-carcinoma tissues were detected by immunohistochemistry. The correlation between 8-OHdG expression and p-EGFR expression was analyzed by Spearman rank correlation analysis.Results Both 8-OHdG and p-EGFR were highly expressed in the TSCC tissues, and their positive rates were 80.0%, 56.7% respectively, whereas the low expressions which were shown with positive rate of 16.7%, 6.7% respectively, were observed in the adjacent-carcinoma tissues. The expressions of 8-OHdG and p-EGFR in carcinoma tissue were significantly higher than those in the adjacent-carcinoma tissue(P<0.05), and the statistically significant correlation was observed between 8-OHdG expression and p-EGFR expression(P<0.05).Conclusion Reactive oxygen species express in oral cancer, which is positively correlated to p-EGFR. |
| Key words: Reactive oxidative species（ROS） Phospho-epithelial growth factor receptor（p-EGFR） Tongue squamous cell carcinoma(TSCC) Immunhistochemistry |
