| 摘要: |
| ［摘要］ 目的 探讨-80 ℃低温保存自体外周血干细胞移植(APBSCT)治疗多发性骨髓瘤(MM)的有效性和安全性。方法 对10例MM患者进行APBSCT治疗。采用环磷酰胺(CTX)+粒细胞集落刺激因子(G-CSF)方案动员干细胞,CS-3000血细胞分离机采集外周血干细胞并保存于-80 ℃冰箱；用马法兰200 mg/m2方案预处理后，解冻回输冻存的干细胞。结果 (1)动员后获得单个核细胞数（MNC）中位数为4.54(2.31～9.80)×108/kg；CD34+细胞数中位数为4.17(2.03～7.76)×106/kg。(2)移植后10例患者均获得造血重建，中性粒细胞计数>0.5×109/L、血小板计数>20×109/L的中位时间分别是13.3(9～16)d、15(11～19)d。(3)移植后3个月完全缓解(CR)8例，非常好的部分缓解(VGPR)2例。中位随访54.6(3～111)月，生存8例(CR5例，VGPR 3例)，其中无进展生存6例。复发4例中再次治疗维持CR 2例，多次复发死亡2例。(4)移植的并发症是感染，无移植相关死亡。结论 -80 ℃低温保存APBSCT治疗MM安全有效，近期疗效好，移植后需要长期维持治疗。 |
| 关键词: 多发性骨髓瘤 自体外周血干细胞移植 疗效 |
| DOI：10.3969/j.issn.1674-3806.2016.07.04 |
| 分类号:R 733.3 |
| 基金项目:广西卫计委科研课题（编号：Z2008048） |
|
| A clinical study of autologous peripheral blood stem cell transplantation in multiple myeloma |
|
LAN Mei, LIN Jin-ying, TANG Yang-ming, et al.
|
|
Department of Hematology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Objective To observe the efficacy and safety of autologous peripheral blood stem cell transplantation(APBSCT) in multiple myeloma(MM).Methods Ten patients with MM received APBSCT. The peripheral stem cells were mobilized with cyclophosphamide(CTX) plus granulocyte colony stimulating factor(G-CSF) and were collected with CS-3000 Cell Separator and preserved in a refrigerator at -80 ℃. After the pretreatment of melphalan at 200 mg/m2, the peripheral blood stem cells were defrosted and reinfused into the patients.Results The median mononuclear cells and CD34+ cells were 4.54(2.31～9.80)×108/kg and 4.17(2.03～7.76)×106/kg, respectively. All patients were engrafted. The median time of neutrophil count>0.5×109/L and platelet count>20×109/L were 13.3(9～16)days and 15(11～19)days, respectively.(3)Eight patients had complete response(CR) and two patients had very good partial response(VGPR) three months after the transplantation. With a median follow-up of 54.6(3～111)months, eight patients survived and six patients were progression-free survival(PFS). Four patients relapsed. After active treatment, two patients were CR and two patients died of relapse. Infections were the major complications. There was not transplant-related mortality.Conclusion APBSCT with cryopreservation peripheral stem cells at -80 ℃ is safe and effective for MM. The short-term effects are remarkable, but the disease needs a long-term maintenance treatment after the transplantation. |
| Key words: Multiple myeloma Autologous peripheral blood stem cell transplantation Therapy |
